Local steroid injections offer swift and effective relief from pain and inflammation. However, it’s essential to note that these benefits are typically temporary. Like all medications, some individuals may experience side effects. The purpose of this patient information leaflet is to provide you with comprehensive information. We kindly request written consent from all patients before any injection to ensure they have read and understood this information.
Understanding Steroids and their use
Some steroids occur naturally in the human body, while others are synthesized to mimic the natural ones, reducing inflammation. Steroids can be administered orally or through injections. They find applications in various medical fields to treat inflammatory conditions.
Steroids are often recommended for individuals experiencing musculoskeletal pain, such as inflammatory arthritis or osteoarthritis, as well as a range of other soft tissue conditions involving pain and inflammation.
Steroids used in injections may take up to 2 weeks to reach full effect, and pain relief can extend from several weeks to several months post-injection.
It’s crucial to understand that not all patients will respond the same way, with some experiencing no relief.
When should steroid injections not be used?
Injections are not suitable for all patients. Please inform your clinician if you believe any of the following may apply to you:
- Allergy to steroid or local anaesthetic
- Infection close to the site of the proposed injection or a significant infection elsewhere
- Broken skin or rash at the site of the proposed injection
- A tendency to bleed more readily as a result of illness or medication
- Surgical metalwork at the site of the proposed injection, for example a joint replacement, screws, plates etc.
The Injection Process
- A clinical assessment and the use of an ultrasound scan help pinpoint the source of pain and deliver the injection more accurately.
- The clinician performing your injection will select the most suitable steroid and dosage for your condition.
- The injection is typically administered directly into the inflamed area, such as a joint or soft tissue.
- Our clinic has strict infection control measures in place, which will be followed throughout the injection process. Most injections are quick and straightforward.
After the Injection
- If you receive a local aesthetic, you may experience immediate pain relief, but this effect usually subsides within a few hours. The steroid’s full effect may take several days, and in some cases, up to 2-3 weeks, to manifest.
- It’s advisable to arrange alternate transportation, especially if you receive a local aesthetic that can cause numbness and make driving challenging. Some patients might experience post-injection pain, so plan your journey accordingly. You are welcome to bring a friend or family member along to your appointment.
- After a joint injection, it’s recommended to avoid strenuous exercise for up to two days. This advice may vary depending on your specific injury, so discuss it with your treating clinician.
- If the injection is around a tendon, you may be asked to avoid heavy impact and loading activities for up to two weeks, depending on your injury and circumstances.
- While a doctor’s referral is not mandatory for an injection, we provide a report after the procedure that we suggest forwarding to your GP for your medical records.
- The injection site should be kept clean and dry for 24 hours post-injection.
Need for Future Injections
If you find the injection beneficial, and other treatments are ineffective, it may be repeated. However, injections are often used as a means to facilitate exercise and rehabilitation. Once your pain is better managed, the need for injections should decrease. Current guidelines recommend limiting the number of steroid injections in the same area to a maximum of three within a 12-month period.
Risks and Side Effects:
Most people tolerate steroid injections well without significant side effects. The risk of side effects may be slightly higher with stronger, longer-acting steroids like Triamcinolone acetonide and Methylprednisolone, which provide extended treatment effects. For safety reasons, if you have unstable blood pressure or uncontrolled blood sugar levels due to diabetes, your clinician may delay your injection until you obtain consent from your GP.
- Steroid injections may temporarily suppress the immune system, which is a factor to consider in relation to Covid-19. A two-week interval is recommended between receiving a COVID vaccine and having a steroid injection to ensure vaccine effectiveness.
- Pain and Discomfort: While there can be some discomfort during the injection, many individuals find it less uncomfortable than expected. This discomfort is usually brief and quickly resolves.
- Potential Increase in Pain: Approximately one in four people may experience increased pain (post-injection flare) within the first 24 hours following the injection. This typically subsides within a few days and can be managed with pain relievers like paracetamol and cold compresses. In rare cases, post-injection flare can be more pronounced and last up to a week.
- Very rarely, severe pain (known as pseudo-sepsis) can occur, and in such instances, immediate medical attention is necessary.
- Osteonecrosis: The risk of osteonecrosis is highest with prolonged, high doses of exogenous steroids, particularly in the presence of other risk factors. Short courses of steroids however have also been shown to increase the risk of this very rare complication.
- Skin Changes: Occasionally, injections may cause thinning and changes in skin color at the injection site (depigmentation). In rare cases, injections into muscles or joints can result in skin indentation (fat atrophy).
- Infection: Infections following an injection are exceedingly rare. If the treated joint or soft tissue becomes more painful, hot, red, and swollen, along with general symptoms like fever and nausea, seek immediate medical attention.
- Weight Gain: Concerns about weight gain following a steroid injection are unwarranted. Injected steroids can be administered in low doses, minimizing the risk of systemic side effects.
- Diabetes: Patients with diabetes may experience fluctuations in blood sugar levels after a steroid injection. Type 1 or insulin-dependent diabetics and those with unstable blood sugar levels HbA1c above 8.5% (70mmol/l) should consult their GP before booking an injection.
- Other Possible Side Effects: facial flushing, temporary menstruation and mood changes, dizziness, and changes in vision or visual acuity.
Taking Other Medications
You can take other medications alongside local steroid injections. However, for specific conditions like diabetes, cancer, or HIV, it’s advisable to consult your GP or treating consultant to ensure the injection’s safety.
Pregnancy and Breastfeeding
Steroid injections are not offered to pregnant patients. If you are breastfeeding, please ask your therapist for guidance using a leaflet from the Breast Feeding Network in 2014.
Summary of Risks and Side Effects
-
- Serious side effects are rare and may include joint and soft tissue infections (approx. 1 in 50,000) and anaphylaxis (extremely rare, but requires immediate medical attention)
- Other potential side effects include the risk of tendon rupture (mostly associated with weightbearing tendons), temporary immunosuppression (considering Covid-19), local subcutaneous fat atrophy, local depigmentation, post-injection flare of pain (usually mild, but occasionally more severe), destabilization of blood sugar levels in diabetics, blurring of vision, and other very rare complications.
You will be observed for 20 minutes after the injection to monitor any possible adverse reactions.
If you have questions or require further information, please call 01635 767 003 or email info@geckofitness.com, and we will arrange for one of our clinical specialists to speak with you.
Cost of Steroid Injections
Cost per injection: £270 (Reviewed September 2023)
References
Joint and soft tissue Injection recommendations PCRMM , Dr Lucy Douglas
BSc Hons MB ChB MRCP (1997) DCH DTM&H JCPTGP MSc (MSK Ultrasound), Updated 2021 https://pcrmm.org.uk/wp-content/uploads/2021/05/609ed17c727f3.pdf Accessed March 2023
1. Stephens M.B, Beutler A. I, O’Connor, F.G. Musculoskeletal Injections: A Review of the Evidence. Am Fam Physician. 2008 Oct 15; 78(8):971-976.
2. EULAR Textbook on Rheumatic Diseases. Bilsma J W J: BMJ Group First Edition 2012
3. Weitoft T, Larsson A, Saxne T, Rönnblom L: Changes of cartilage and bone markers after intra-articular glucocorticoid treatment with and without post injection rest in patients with rheumatoid arthritis . Ann Rheum Dis 2005; 64:1750-1753
4. Brinks A, Koes B W, Volkers A C W, Verhaar J A N, Bierma-Zeinstra S M A: Adverse effects of extra-articular corticosteroid injections: a systematic review. Musculoskeletal Disorders 2010,11:206
5. Philipose J, Baker K, O’rourke K S, Deodhar A; Joint Aspiration and Injection: A Look at the Basics. Tapping into a valuable diagnostic and treatment resource. The Journal of Musculoskeletal Medicine. Vol. 28 No. 6 07 June 2011
6 mps-essential-guide-to-consent.pdf (azureedge.net) accessed Apr 2021
7. New guidance on decision making and consent – The MDU Accessed May 2021
9. Informed consent | MDDUS Accessed May 202110. Decision making and consent – GMC (gmc-uk.org) Accessed May 2021
11. Andreasen R A, Just S A, Hansen I M J : The risk of intraarticular steroid injections are overestimated. Annals of the Rheumatic Diseases; Jun 2014; vol. 73
12. McGarry J, Daruwalla Z: The efficacy, accuracy and complications of corticosteroid injections of the knee joint Knee Surgery, Sports Traumatology, Arthroscopy Oct2011, Vol. 19 Issue 10, p1649
13. Loveday H P, Wilson J A, Pratt R J, Golsorkhi M, Tingle A, Bak A, Browne J ,Prieto J, Wilcox M: National Evidence-Based Guidelines for Preventing Healthcare-Associated Infections in NHS Hospitals in England http://www.journalofhospitalinfection.com/article/S0195-6701(13)60012-2/fulltext accessed May 2021
14 Infection Control | CDC Accessed May 2021
16. Chang C Y, Furlong L: Microbial Stowaways in Topical Antiseptic Products. N Engl J Med 2012; 367:2170-2173
17. Hemani M L and Lepor H: Skin Preparation for the Prevention of Surgical Site Infection: Which Agent Is Best? Rev Urol. 2009; 11(4): 190–195.
18. Hilliard J G, Cambronne E D, Kirsch J R, Aziz M F: J Clin Anesth. Barrier protection capacity of flip-top pharmaceutical vials 2013 May; 25(3):177-80.
19. Alexander J W, Solomkin J S, Edwards M J: Updated Recommendations for Control of Surgical Site Infections. Annals of Surgery. 2011; 253(6):1082-1093
20. Cawley PJ, Morris I M: A Study To Compare The Efficacy Of Two Methods Of Skin Preparation Prior To Joint Injection. British Journal of Rheumatology, 1992, 31(12):847-848
21. Kampf G: Acquired resistance to chlorhexidine – is it time to establish an ‘antiseptic stewardship’ initiative? The Journal of hospital infection; Nov 2016; vol. 94 (no. 3); p. 213- 227
22. Oh J, Jo L, Lee J I: Do not rush to return to sports after trigger finger injection American journal of physical medicine & rehabilitation / Association of Academic physiatrists; Apr 2015; vol. 94 (no. 4)
23. Nanno M, Sawaizumi T, Kodera N, Tomori Y, Takai S: Flexor pollicis longus rupture in a trigger thumb after intrasheath triamcinolone injections: A case report with literature review. Journal of Nippon Medical School; 2014; vol. 81 (no. 4); p. 269-275
24. Yadkikar SV, Yadkikar VS, Gandhi D R, Jalindhra V: bilateral atraumatic tendoachilles rupture following steroid injection – A rare clinical presentation. Pravara Medical Review; 2015; vol. 7 (no. 2); p. 18-21
25. Dean B J F, Lostis E, Oakley T, Rombach I, Morrey M E, Carr A J: the risks and benefits of glucocorticoid treatment for tendinopathy: A systematic review of the effects of local glucocorticoid on tendon. 2014 Seminars in Arthritis & Rheumatism: 43(4): 570-576
26. Fredberg, U. Local corticosteroid injection in sport: review of literature and guidelines for treatment. Scandinavian Journal of Medicine & Science in Sports June 1997: Vol. 7 Issue 3. p. 131-139
27. Yang S L, Zhang Y B, Jiang Z T, Li Z Z, Jiang D P: Lidocaine potentiates the deleterious effects of triamcinolone acetonide on tenocytes Medical Science Monitor: International Medical Journal Of Experimental And Clinical Research ISSN: 1643-3750, 2014 Nov 29; Vol. 20, pp. 2478-83
28. Clinical manifestations and diagnosis of osteonecrosis (avascular necrosis of bone) – UpToDate Accessed May 2021
29. Dilisio M F: Osteonecrosis Following Short-term, Low-dose Oral Corticosteroids: A Population-based Study of 24 Million Patients. Orthopedics (Online); Thorofare 37.7 (Jul 2014): e631-6.
30. Kassam A.M: Accelerated avascular necrosis after single intra-articular injection of corticosteroid into the hip joint. BMJ Case Rep. 2010; bcr1020092405.
Published online 2010 Oct 8
31. Conway R, O’Shea F D, Cunnane G, Doran M F : Safety of joint and soft tissue injections in patients on warfarin anticoagulation. Clinical Rheumatology. December 2013, Volume 32, Issue 12, pp 1811-1814
32. Thumboo J, O’Duffy JD: A prospective study of the safety of joint and soft tissue aspirations and injections in patients taking warfarin sodium. Arthritis Rheum. April 1998;41:736–9.
33. Ahmed I, Gertner E: Safety of arthrocentesis and joint injection in patients receiving anticoagulation at therapeutic levels. Am J Med. 2012 Mar;125(3):265-9.
34. Bashir M A, Ray R, Sarda P, Li S, Corbett S :Determination of a safe INR for joint injections in patients taking warfarin Ann R Coll Surg Engl. 2015 Nov 1; 97(8): 589–591
35. Management of bleeding in patients receiving direct oral anticoagulants – UpToDate Accessed May 2021
36. Medical Information Updated 10 October 2013. Boehringer Ingelheim Pradaxa® (dabigatran etexilate) Minor invasive procedures in patients treated with dabigatran.
37. Xarelto® (rivaroxaban) Enquiry 0058320/UK medical.information@bayer.co.uk [medical.information@bayer.co.uk] Dec 2013
38. Burnett A , Siegal D, Crowther M: Specific antidotes for bleeding associated with direct oral anticoagulants BMJ 2017; 357 doi: https://doi.org/10.1136/bmj.j2216
39. Yip S W, and Chan Y C: Antidotes for patients taking novel oral anti-coagulants. World J Emerg Med. 2015; 6(4): 311–312.
40. Steroid injections – NHS (www.nhs.uk) accessed May 2021
41. Douglas R J: Corticosteroid injection into the osteoarthritic knee: drug selection, dose, and injection frequency. International Journal Of Clinical Practice [Int J Clin Pract], ISSN: 1742-1241, 2012 Jul; Vol. 66 (7), pp. 699-704
42. Neustadt D H: Intra-articular injections for osteoarthritis of the knee. 5. Cleve. Clin J Med 2006; 73: 897-8, 901-4, 906-11
43. Hartmann K, Koenen M, Schauer S, Wittig-Blaich S, Ahmad M, Baschant U, Tuckermann J P: Molecular Actions of Glucocorticoids in Cartilage and Bone During Health, Disease, and Steroid Therapy. Physiological Reviews Published 3 February 2016 Vol. 96 no. 2, 409-447
44. O’sullivan M M, Rumfeld W R, Jones M K, Williams B D. Case report; Cushing’s syndrome with suppression of the hypothalamic-pituitary-adrenal axis after intra-articular steroid injections. Annals of the Rheumatic Diseases 1985,44,561-563
45. Johnston P C, Lansang M C, Chatterjee S, Kennedy L: Intra-articular glucocorticoid injections and their effect on hypothalamic-pituitary-adrenal (HPA)-axis function. Endocrine; Mar 2015; vol. 48 (no. 2); p. 410-416
46. Danaher P J, Salsbury T L, Delmar J A : Metabolic derangement after injection of triamcinolone into the hip of an HIV-infected patient receiving ritonavir. Orthopedics. 2009 Jun;32(6):450.
47. Shumaker P R,Rao J, Goldman M P: Treatment of local, persistent cutaneous atrophy following corticosteroid injection with normal saline infiltration Dermatol Surg 2005:1:1340- 134
48. Papadopoulos P J, Edison J D: The Clinical Picture – Soft tissue atrophy after corticosteroid injection. Cleve Clin J Med. 2009 Jun;76(6):373-4
49. Saunders S and Longworth S: Injection Techniques in Musculoskeletal Medicine 5th Ed,Churchill Livingstone 2018
50. Cardone D A, Tallia A F: Joint And Soft Tissue Injection. Am Fam Physician. 2002 Jul 15;66(2):283-289.
51. Povlsen B, Povlsen S D: Steroid injection for shoulder pain causes prolonged increased glucose level in type 1 diabetics BMJ Case Reports; Sep 2014; vol. 2014
52. Kallock E, Neher J O, Safranek S: Do intra-articular steroid injections affect glycemic control in patients with diabetes? December 2010 · Vol. 59, No. 12: 709-710
53. Catalano L W, Steven S Z, Alton Barron O, Harrison R, Marshall A: Purcelli-Lafer M, Effect of Local Corticosteroid Injection of the Hand and Wrist on Blood Glucose in Patients With Diabetes Mellitus.Orthopedics. December 2012 – Volume 35 · Issue 12: e1754-e1758
54 For health professionals and healthcare organisations | Resuscitation Council UK Accessed May 2021
55. Weitoft T, Rönnblom L: Randomised controlled study of post injection immobilisation after intra-articular glucocorticoid treatment for wrist synovitis Ann Rheum Dis 2003; 62:1013-1015 doi:10.1136/ard.62.10.1013.
56.Wallen M M, Gillies: Intra-articular steroids and splints/rest for children with juvenile idiopathic arthritis and adults with rheumatoid arthritis. Editorial Group: Cochrane Musculoskeletal Group Published Online: 25 JAN 2006
57. Chatham W, Williams G, Moreland L, ParkerJ W, Ross C, Alarcon S G, Alarcon G S: Intraarticular corticosteroid injections: Should we rest the joints? Arthritis Care and Research Volume 2, Issue 2, 1989, Pages 70-74. Ann Rheum Dis 2003; 62:1013-1015
58. COVID-19 vaccination and MSK (arma.uk.net) accessed May 2021
59. Musculoskeletal-steroid-injection-and-concurrent-influenza-vaccination-analysis-of-current-
evidence-PCRMM-V4.pdf accessed Mar 2021
60. Mental-capacity-act-code-of-practice.pdf (publishing.service.gov.uk) accessed May 2021
61.Assessing Mental Capacity – UK Definition & Principles | MDDUS accessed May 2021
62.Assessing capacity – The MDU accessed May 2021
63. Direct Oral Anticoagulants (DOACs) – UKCPA (ukcpa-periophandbook.co.uk) accessed May 2021
64. WHO guidelines on drawing blood best practices in phlebotomy (Eng) Accessed May 2021
65. Peri-Operative Management of Anticoagulation and Antiplatelet Therapy | British Society for Haematology (b-s-h.org.uk) Accessed May 2021
66. Anticoagulation – oral | Health topics A to Z | CKS | NICE Accessed May 2021


